Eva Horáková

ORCID: 0000-0002-3730-8979

Research Interests

My main research interest is the cell biology of protists. In my previous work, I focused on heme metabolism in trypanosomes and related organisms. Currently, my interest extends to other protists such as Tetrahymena, Phaeodactylum, and Chlamydomonas, where we study different biosynthetic pathways such as for phosphonates, carotenoids and chlorophylls.

Curriculum vitae

• 2021 – Present, Co-leader, Centre Algatech, Institute of Microbiology, Czech Academy of Sciences, Třeboň 
• 2010 – 2022, Research Scientist, Laboratory of Molecular Biology of Protists, Institute of Parasitology, Biology Centre of the Czech Academy of Sciences, České Budějovice
• 2022, Visiting Scientist, Prof. Roberto Docampo, Department of Cellular Biology, University of Georgia, Georgia, USA
• 2020, Visiting Scientist, Prof. Isabel Roditi Laboratory, Institute of Cell Biology, University of Bern, Switzerland
• 2018, Visiting Scientist, Laboratory of Neurovascular Signaling (head Prof. Benoit Vanhollebeke), University of Brussels, Belgium
• 2009 – 2010, Postdoctoral Researcher, Department of Medical Genetics, Vancouver Coastal Health Research Institute, University of British Columbia, Canada
• 2006 – 2008, Maternity leave
• 2003, Visiting Ph.D.student, Prof. Kenneth Stuart Laboratory, Biomedical Research Institute, Seattle, Washington, USA
• 2002, Visiting Ph. D. student, Prof. Rob Benne Laboratory, Department of Biochemistry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

Top 5 publications

1. Horáková, E., Vrbacký, M., Tesařová, M., Stříbrná, E., Pilný, J., Vavrušková, Z., Vancová, M., Sobotka, R., Lukeš, J., & Perner, J. (2024). Haptoglobin is dispensable for haemoglobin uptake by Trypanosoma brucei. Frontiers in Immunology, 15, 1441131.     https://doi.org/10.3389/fimmu.2024.1441131
2. Kachale, A., Pavlíková, Z., Nenarokova, A., Roithová, A., Durante, I. M., Miletínová, P., Záhonová, K., Nenarokov, S., Votýpka, J., Horáková, E., Ross, R. L., Yurchenko, V., Beznosková, P., Paris, Z., Valášek, L. S., & Lukeš, J. (2023). Short tRNA anticodon stem and mutant eRF1 allow stop codon reassignment. Nature, 613(7945), 751–758. https://doi.org/10.1038/s41586-024-07065-0
3. Horáková, E., Lecordier, L., Cunha, P., Sobotka, R., Changmai, P., Langedijk, C. J. M., Abbeele, J. V. D., Vanhollebeke, B., & Lukeš, J. (2022). Heme-deficient metabolism and impaired cellular differentiation as an evolutionary trade-off for human infectivity in Trypanosoma brucei gambiense. Nature communications, 13(1), 7075. https://doi.org/10.1038/s41467-022-34501-4
4. Kořený, L., Oborník, M., Horáková, E., Waller, R. F., & Lukeš, J. (2021). The convoluted history of haem biosynthesis. Biological reviews of the Cambridge Philosophical Society, 10.1111/brv.12794. https://doi.org/10.1111/brv.12794
5. Horáková, E., Changmai, P., Vancová, M., Sobotka, R., Van Den Abbeele, J., Vanhollebeke, B., & Lukeš, J. (2017). The Trypanosoma brucei TbHrg protein is a heme transporter involved in the regulation of stage-specific morphological transitions. The Journal of biological chemistry,292(17), 6998–7010. https://doi.org/10.1074/jbc.M116.762997